Biosensing of reconfigurable analytes using integrated nanophotonics (brain)

A method, comprising:

• providing at least one light source;
• providing a solution with analyte molecules;
• providing a photonic integrated circuit element with a surface attaching to the surface receptor molecules;
• flowing the solution with analyte molecules over the surface of the photonic integrated circuit element;
• engaging the light source and binding the analyte molecules to the receptor molecules.

A method of reusing or reconfiguring a photonic integrated circuit, comprising:

• providing at least one photonic integrated circuit with at least one used element;
• configuring a lighting pattern to interact with the at least one used element;
• exposing the at least one used element to light in the lighting pattern, releasing secondary receptor molecules from base receptor molecules;
• flowing at least a first washing solution over the at least one used element, removing the released secondary receptor molecules creating a cleaned element;
• flowing at least a first recharging solution with new secondary receptor molecules over the cleaned element;
• exposing the new secondary receptor molecules and the cleaned element to light in the lighting pattern, binding the new secondary receptor molecules to the base receptor molecules;
• and,
• optionally repeating the above steps for one or more additional elements in series or in parallel.