Tyr peptide compositions and methods for use
AssigneeUniversity of Miami
InventorKarina Galoian
Life of this patent
Estimating the term…
Abstract
The present disclosure, relates, in general to analogs of proline-rich polypeptide 1 (PRP-1) designated tyrosine peptides (TYR peptide) that are useful to treat cancer, such as sarcomas, carcinomas and leukemias or liquid cancers.
Claims34
A peptide analog of proline rich polypeptide-1 (PRP-1) (AGAPEPAEPAQPGVY, SEQ ID NO:
- 1) which is a tyrosine peptide (TYR peptide) having an amino acid sequence at least 70% identical to SETPEPKGPADPELY (SEQ ID NO:
- 2).
A cyclic TYR peptide having the sequence Cyclo(SETPEPKGPADPELY (PO3H2).
A method of treating cancer in a subject comprising administering a composition comprising a peptide analog of proline rich polypeptide-1 (PRP-1) which is a tyrosine peptide (TYR peptide) having an amino acid sequence at least 70% identical to SETPEPKGPADPELY (SEQ ID NO:
- 2).
A method of treating a sarcoma in a subject comprising administering a composition comprising a peptide analog of proline rich polypeptide-1 (PRP-1) which is a tyrosine peptide (TYR peptide) having an amino acid sequence at least 70% identical to SETPEPKGPADPELY (SEQ ID NO:
- 2).
A method of treating a leukemia in a subject comprising administering a composition comprising a peptide analog of proline rich polypeptide-1 (PRP-1) which is a tyrosine peptide having an amino acid sequence at least 70% identical to SETPEPKGPADPELY (SEQ ID NO:
- 2).
A method of treating a carcinoma in a subject comprising administering a composition comprising a peptide analog of proline rich polypeptide-1 (PRP-1) which is a tyrosine peptide (TYR peptide) having an amino acid sequence at least 70% identical to SETPEPKGPADPELY (SEQ ID NO:
- 2).
The method of claim 22, wherein the TYR peptide eliminates 15% or more of cancer stem cells (CSC) in a subject.
The method of any one of claims 8-29, wherein the TYR peptide is administered with a second agent or standard of care therapy.
Dependencies are inferred from the claim text.