Stabilized immunoglobulin domains
AssigneeHoffmann-La Roche Inc.
InventorsLaura CODARRI DEAK, Stefan DENGL, Jens FISCHER, Thomas HOFER, Laurent LARIVIÈRE, Ekkehard MÖSSNER, Stefan SEEBER, Pablo UMAÑA, Anne-Claire ZAGDOUN
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Abstract
The invention relates autonomous VH domains (aVH) with cysteines in positions 52a and 71 or in positions 33 and 52 in order to stabilize the autonomous VH domains. Said cysteines are capable of forming a disulfide bond and/or form a disulfide bond under suitable conditions. The invention further relates to aVH libraries.
Claims25
An autonomous VH domain with cysteines in positions (i) 52a and 71 or (ii) 33 and 52 according to Kabat numbering, wherein said cysteines are capable of forming a disulfide bond and/or form a disulfide bond under suitable conditions.
25-26. (canceled)
Dependencies are inferred from the claim text.