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US 2026/0070930 A1Published application
Ras inhibitors
AssigneeRevolution Medicines, Inc.
InventorsYang LIU, James CREGG
Life of this patent
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Abstract
The disclosure features macrocyclic compounds, and pharmaceutical compositions and protein complexes thereof, capable of inhibiting Ras proteins, and their uses in the treatment of cancers.
Claims30
A compound having the structure of Formula Int-1:
- or a salt thereof, wherein:
- Q is hydrogen, —B(OH)2,
- or halogen;
- Z is hydrogen or optionally substituted C1-C6 alkyl;
- Y is halogen, —B(OH)2,
- -CO2H, —CO2—(C1-C6 alkyl), or —CN;
- E is
- and
- PNG is a protecting group.
6 more elements
A compound selected from the group consisting of:
A compound selected from the group consisting of:
Dependencies are inferred from the claim text.