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US 2026/0069724 A1Published application
Methods and materials for making pet radiotracers
AssigneeCellSight Technologies Inc.
InventorsJelena Levi, Ananth Srinivasan, Alexander Hoepping, Rene Smits
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Abstract
Embodiments of the present disclosure provide compositions comprising compounds useful to make radiotracers for positron emission tomography imaging, as well as methods for making and using these compositions.
Claims12
A method of making a PET probe composition, the method comprising:
- reacting a compound including an isotope with precursor 1:
- wherein:
- tBu comprises a tert-Butyloxycarbonyl alcohol protecting group;
- Boc comprises a tert-Butyloxycarbonyl amine protecting group;
- THP comprises a tetrahydropyranyl alcohol protecting group;
- EOE comprises an ethoxyethyl alcohol protecting group;
- and
- Tf comprises a triflate leaving group:
- wherein said reacting removes protecting group and leaving group moieties and couples the isotope to the compound;
- so that the PET probe composition is made, wherein the PET probe composition comprises:
7 more elements
A method of making a PET probe composition, the method comprising:
- reacting a compound including an isotope with precursor 3:
- wherein:
- tBu comprises a tert-Butyloxycarbonyl alcohol protecting group;
- Boc comprises a tert-Butyloxycarbonyl amine protecting group;
- THP comprises a tetrahydropyranyl alcohol protecting group;
- EOE comprises an ethoxyethyl alcohol protecting group;
- and
- Tf comprises a triflate leaving group:
- wherein said reacting removes protecting group and leaving group moieties and couples the isotope to the compound;
- so that the PET probe composition is made, wherein the PET probe composition comprises:
7 more elements
Dependencies are inferred from the claim text.