Methods for distinguishing lung cancer from non-cancer

A method for detecting lung cancer associated proteomic markers, the method comprising:

• (a) measuring an amount or a concentration of the lung cancer associated proteomic markers in a biofluid sample obtained from a subject or a processed sample therefrom to obtain proteomic measurements;
• and
• (b) applying a classifier to the proteomic measurements to provide a quantitative or qualitative result for the biofluid sample of lung cancer using fewer than 100 features from the proteomic measurements, wherein the classifier is trained to distinguish lung cancer samples from non-cancer samples with a performance characteristic comprising an area under the curve of at least 0.75.