Diagnosis and localization of disease states with an ensemble of feature-fused top-performing quantitative parameter arrays

A system for disease diagnosis, the system comprising:

• a computer system having at least one computer processor and associated memory containing computer program instructions which, when executed by the at least one computer processor, performs computer processes comprising:
• receiving digital tissue images showing tissue details at a cellular level;
• performing automated image analysis on the received digital tissue images to identify cells of interest for analysis;
• calculating a range of mathematical parameters on multiple levels for collective use as a universal biomarker array including a pattern array, a distance array, a morphology array, a spatial entropy array, a bin array in which absolute parameter values are translated to relative information by assigning them to specific bin positions, and a quartile array in which absolute parameter values are translated to relative information by assigning values to specific quartiles;
• and
• analyzing the universal biomarker array relative to database-based reference data for early diagnosis and localization of disease processes.

A computer program product comprising at least one tangible, non-transitory computer readable medium having embodied therein computer program instructions for disease diagnosis which, when executed by at least one computer processor, performs computer processes comprising:

• receiving digital tissue images showing tissue details at a cellular level;
• performing automated image analysis on the received digital tissue images to identify cells of interest for analysis;
• calculating a range of mathematical parameters on multiple levels for collective use as a universal biomarker array including a pattern array, a distance array, a morphology array, a spatial entropy array, a bin array in which absolute parameter values are translated to relative information by assigning them to specific bin positions, and a quartile array in which absolute parameter values are translated to relative information by assigning values to specific quartiles;
• and
• analyzing the universal biomarker array relative to database-based reference data for early diagnosis and localization of disease processes.