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AssigneeKorea National Institute of Health
InventorsSeung Hee LEE, Su Yeon CHO, Won-Ho KIM
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The present invention relates to a composition for preventing or treating diabetic cardiomyopathy comprising an MsrB2 activator as an active ingredient. The MsrB2 activator disclosed in the present invention suppresses oxidative damage of ROS, induces autophagy in mitophagy, increases mitochondrial regeneration and biosynthesis in diabetic heart tissue, thereby suppressing overall myocardial function decline, so that it can be effectively used in a pharmaceutical composition or health food composition for preventing or treating diabetic cardiomyopathy, particularly diabetic heart disease in lean diabetes.
A method for preventing or treating diabetic cardiomyopathy, comprising administering a pharmaceutical composition comprising an MsrB2 activator as an active ingredient.
A method for determining diabetic cardiomyopathy in a subject comprising:
A screening method for an substance having preventive or therapeutic activity against diabetic cardiomyopathy, comprising the following steps:
Dependencies are inferred from the claim text.