Compositions, systems, and methods for detection of metals

Abstract

Disclosed herein are compositions, systems, and methods for measuring analytes in a complex sample. Nanopore DNA zyme-based detection of certain metal contaminants is disclosed herein. Applicants constructed a multi-DNAzyme array and used a pattern-based readout to improve sensor accuracy. Applicants measured cross-reactivity between a variety of metal cofactors and common interferents and then used kinetic data to quantify the competing metal ion present in solution. The general inventive concepts provide means for detecting complex mixtures of analytes/metals in samples without the need of complex instrumentation.

Dependencies are inferred from the claim text.