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US 2026/0062731 A1Published application
A loopable translator for the synthesis of repetitive proteins
AssigneeThe Johns Hopkins University
InventorsStephen D. Fried, Sea On Lee
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Abstract
The present disclosure is directed to a genetic construct for performing loopable translation, a kit comprising the genetic construct, and a method of producing biomaterials comprising a highly repetitive protein by use of the genetic construct.
Claims39
A genetic construct for performing loopable translation, the construct comprising in the following order:
- (i) a 3′ portion of a Group I self-splicing intron;
- (ii) a C-terminal portion of a gene of interest, wherein the C-terminal portion of the gene of interest comprises a 3′-exonic context sequence at its 5′ end;
- (iii) a ribosome binding site (RBS);
- (iv) a N-terminal portion of the gene of interest, wherein the N-terminal portion of the gene of interest comprises a 5′-exonic sequence at its 3′ end;
- and (v) a 5′ portion of the Group I self-splicing intron.
2 more elements
Dependencies are inferred from the claim text.