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US 2026/0062709 A1Published application
Methods for improving production of biological products by reducing the level of endogenous protein
OwnerRobert YOUNG, Peter Michael O'CALLAGHAN +2inventors
InventorsRobert YOUNG, Peter Michael O'CALLAGHAN, David JAMES, Stephen JAFFE
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Abstract
The present disclosure features methods, cells or cell lines, and compositions for increasing the amount of products, e.g., proteins, produced by a cell or cell line by reducing the level of a non-essential endogenous protein.
Claims24
1-6. (canceled)
A method of making a cell, e.g., a production cell, the method comprising:
- reducing the level of an endogenous protein in the cell, e.g., production cell,
- wherein the cell, e.g., production cell, is capable of expressing a product, e.g., recombinant polypeptide.
29-63. (canceled)
Dependencies are inferred from the claim text.