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US 2026/0062697 A1Published application
Modified messenger rna comprising functional rna elements
AssigneeModernaTX, Inc.
InventorsMelissa J. MOORE, Caroline KÖHRER, Ruchi JAIN, Vladimir PRESNYAK
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Abstract
The present disclosure provides messenger RNAs (mRNAs) having chemical and/or structural modifications, including RNA elements and/or modified nucleotides, which provide a desired translational regulatory activity to the mRNA.
Claims20
1-65. (canceled)
A messenger RNA (mRNA) comprising
- (i) a 5′ untranslated region (UTR) comprising an RNA element as set forth in SEQ ID NO:
- 2;
- and
- (ii) an open reading frame comprising an initiation codon and encoding a polypeptide;
- wherein the RNA element has a 3′ end located 10-20 nucleotides or 6-10 nucleotides upstream of the initiation codon in the 5′UTR, and
- wherein the mRNA comprises one or more chemically modified nucleotides.
3 more elements
A mRNA comprising
- (i) a 5′ UTR comprising an RNA element inserted into the nucleotide sequence set forth in SEQ ID NO:
- 33, and
- (ii) an open reading frame comprising an initiation codon and encoding a polypeptide;
- wherein the RNA element is CCCCGGCGCC (SEQ ID NO:
- 2),
- wherein the RNA element has a 3′ end located 10-20 nucleotides or 6-10 nucleotides upstream of the initiation codon in the 5′ UTR, and
- wherein the mRNA comprises one or more chemically modified nucleotides.
4 more elements
A mRNA comprising
- (i) a 5′ UTR comprising a nucleotide sequence as set forth in SEQ ID NO:
- 34;
- and
- (ii) an open reading frame comprising an initiation codon and encoding a polypeptide,
- wherein the mRNA comprises one or more chemically modified nucleotides.
2 more elements
Dependencies are inferred from the claim text.