Use of multitargeted polypeptide in treatment of organ fibrosis

Abstract

The present disclosure relates to use of a multitargeted polypeptide in the treatment of organ fibrosis, in particular to use of a polypeptide mini-klotho and its gene therapy vectors and methods for the treatment of renal fibrosis, hepatic fibrosis, pulmonary fibrosis and other organ fibrosis. The present disclosure provides the use of mini-klotho in the treatment of renal, hepatic and pulmonary fibrosis models, with significant therapeutic effects and without obvious toxic or side effects. Therefore, the mini-klotho of the present disclosure can be prepared into a pharmaceutical preparation for the treatment of organ fibrosis.

Dependencies are inferred from the claim text.