Genetically engineered placental mucosalassociated invariant t (mait) cells and uses thereof
AssigneePluri Biotech Ltd.
InventorsArthur MACHLENKIN, Adi SHARBI-YUNGER, Eliran ISH SHALOM, Helena Lea SHAKED
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Abstract
This invention is directed in one main aspect to a cell composition comprising a population of engineered mucosal-associated invariant T (MAIT) cells derived from placental tissue expressing an exogenous chimeric antigen receptor (CAR). The invention further discloses a unique placental MAIT cell population, cell compositions comprising the MAIT cell population, and methods of use.
Claims64
A cell composition comprising a population of mucosal-associated invariant T (MAIT) cells expressing an exogenous chimeric antigen receptor (CAR), wherein said MAIT cells are derived from placental tissue, and further comprising an antigen-binding domain, a transmembrane domain, and an intracellular signaling domain, and optionally, the composition further comprising a pharmaceutically acceptable carrier.
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Dependencies are inferred from the claim text.