Antibodies against tl1a and uses thereof
AssigneeEarendil Labs Inc.
InventorsJian HUANG, Zhenping ZHU, Jian PENG, Liang TIAN, Chenpeng SU, Hao RAN
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Abstract
The present disclosure provides an isolated antigen-binding protein specifically binding to TNF-like protein A (TL1A), comprising a heavy chain variable region (VH) comprising at least one heavy chain complementarity-determining region (HCDR) comprising an amino acid sequence shown in SEQ ID NO:1, SEQ ID NO:5, or SEQ ID NO:14.
Claims14
An isolated antigen-binding protein specifically binding to TNF-like protein A (TL1A), comprising a heavy chain variable region (VH) including heavy chain complementarity determining regions (HCDRs) 1-3 and a light chain variable region (VL) including light chain complementarity determining regions (LCDRs) 1-3, wherein
- the VH comprises HCDR1 as set forth in SEQ ID NO:
- 1, HCDR2 as set forth in SEQ ID NO:
- 5, HCDR3 as set forth in SEQ ID NO:
- 14, and the VL comprises LCDR1 as set forth in SEQ ID NO:
- 42, LCDR2 as set forth in SEQ ID NO:
- 43, and LCDR3 as set forth in SEQ ID NO:
- 44:
- or, the VH comprises HCDR1 as set forth in SEQ ID NO:
- 107, HCDR2 as set forth in SEQ ID NO:
- 115, HCDR3 as set forth in SEQ ID NO:
- 120, and the VL comprises LCDR1 as set forth in SEQ ID NO:
- 154, LCDR2 as set forth in SEQ ID NO:
- 159, and LCDR3 as set forth in SEQ ID NO:
- 163:
- or the VH comprises HCDR1 as set forth in SEQ ID NO:
- 235, HCDR2 as set forth in SEQ ID NO:
- 238, HCDR3 as set forth in SEQ ID NO:
- 242, and the VL comprises LCDR1 as set forth in SEQ ID NO:
- 269, LCDR2 as set forth in SEQ ID NO:
- 274, and LCDR3 as set forth in SEQ ID NO:
- 277.
Dependencies are inferred from the claim text.