Back to results
US 2026/0062491 A1Published application
Cd40l 41bbl bispecific proteins
AssigneeH. Lee Moffitt Cancer Center and Research Institute, Inc.
InventorsVincent LUCA, Patrick HWU, Daniel ABATE-DAGA, Renata Marques ROSSETTI
Life of this patent
Estimating the term…
Abstract
In one aspect, disclosed herein are novel multimeric costimulatory agonistic constructs comprising said monomers for expanding tumor infiltrating lymphocytes (TILs) in vitro or ex vivo said methods comprising obtaining TILs and culturing the TILs in media comprising one or more multimeric costimulatory agonists.
Claims25
A multimeric costimulatory agonist construct comprising a CD40 agonist construct and a 4-1BB agonist construct;
- wherein said CD40 agonist construct is connected to said 4-1BB construct.
-18. (canceled)
Dependencies are inferred from the claim text.