Anti-tirc7 antigen binding proteins

A method of modulating a cell-mediated immune response in a human cell that expresses human TIRC7 in a subject, comprising contacting said cell or administering to said subject a therapeutically effective amount of Antigen Binding Protein (ABP) capable of binding to T-cell immune response cDNA 7 (TIRC7), thereby modulating, preferably inhibiting, the cell-mediated immune response, the ABP comprising:

• (i) heavy chain variable domains comprising the CDRH1 region set forth in SEQ ID NO:
• 01, the CDRH2 region set forth in SEQ ID NO:
• 02, and the CDRH3 region set forth in SEQ ID NO:
• 03, or wherein one or more of the CDRH1, CDRH2 and CDRH3 comprise a sequence having no more than one amino acid substitution compared to SEQ ID NO:
• 01, SEQ ID NO:
• 02, or SEQ ID NO:
• 03, respectively;
• and
• (ii) light chain variable domains comprising the CDRL1 region set forth in SEQ ID NO:
• 05, the CDRL2 region set forth in SEQ ID NO:
• 06, and the CDRL3 region set forth in SEQ ID NO:
• 07, or wherein one or more of the CDRL1, CDRL2 and CDRL3 comprises a sequence having no more than one amino acid substitution compared to SEQ ID NO:
• 05, SEQ ID NO:
• 06, or SEQ ID NO:
• 07.