Methods of Treating Red Blood Cell Disorders

A method of promoting differentiation of an erythroid progenitor cell toward a mature red blood cell in a human subject in need thereof, the method comprising administering to the human subject an effective amount of an anti-IL-22 antibody or an antigen binding fragment thereof or an anti-IL-22RA1 antibody or an antigen binding fragment thereof, and wherein the subject is afflicted with an anemia caused by defective erythropoiesis.

A method of treating a red blood cell disorder in a human subject in need thereof, the method comprising administering to the human subject an effective amount of an anti-IL-22 antibody or an antigen binding fragment thereof or an anti-IL-22RA1 antibody or an antigen binding fragment thereof, wherein the red blood cell disorder is selected from myelodysplastic syndrome, acute myelogenous leukemia that has progressed from a myelodysplastic syndrome, an anemia caused by insufficiency of serine/threonine-protein kinase RIOK2, an anemia caused by one or more mutations and/or deletions on human chromosome 5 or in an ortholog thereof, macrocytic anemia, Diamond Blackfan anemia, and Shwachman-Diamond syndrome.