Antibody and use thereof

An isolated antigen-binding protein, comprising:

• a first antigen-binding domain and a second antigen-binding domain, wherein the first antigen-binding domain specifically binds to TNF-like protein A (TL1A), and wherein the second antigen binding domain specifically binds to α4β7.

An isolated nucleic acid molecule encoding an isolated antigen-binding protein, comprising:

• a first antigen-binding domain and a second antigen-binding domain, wherein the first antigen-binding domain specifically binds to TNF-like protein A (TL1A), and wherein the second antigen binding domain specifically binds to α4β7.

A method for preparing an antigen-binding protein the method comprising culturing a host cell comprises one or more nucleic acids encoding an antigen-binding protein comprising a first antigen-binding domain and a second antigen-binding domain, wherein the first antigen-binding domain specifically binds to TNF-like protein A (TL1A), and wherein the second antigen binding domain specifically binds to α4β7, and recovering the antigen-binding protein.

A method of treating a TL1A-mediated disease or condition in a subject in need thereof, the method comprising:

• administrating an antigen-binding protein comprising a first antigen-binding domain and a second antigen-binding domain, wherein the first antigen-binding domain specifically binds to TNF-like protein A (TL1A), and wherein the second antigen binding domain specifically binds to α4β7, thereby treating the disease or condition in the subject.