Fusion protein
OwnerSimon WESTBROOKinventor
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Abstract
The present invention relates to a p75NTR neurotrophin binding protein (NBP)-Fc fusion protein comprising a p75NTR(NBP) portion and an immunoglobulin portion. In certain embodiments. the p75NTR(NBP)-Fc fusion protein is for use in the treatment of pain and/or a symptom of pain.
Claims15
-8. (canceled)
A p75NTR neurotrophin binding protein (NBP)-Fc fusion protein, comprising:
- (a) a p75NTR(NBP) portion with an amino acid sequence having at least 90% identity with a sequence selected from one of Seq ID No. 1 & 2;
- and
- (b) an immunoglobulin Fc portion with an amino acid sequence having at least 90% identity with a sequence selected from one of Seq ID No. 3-6;
- wherein, the p75NTR(NBP) and Fc portions are connected via a linker, the linker comprises a peptide of formula Gx, where x is 1, 2, 3, 4, 5 or 6.
A p75NTR neurotrophin binding protein (NBP)-Fc fusion protein according to claim 1, wherein the p75NTR(NBP) portion is Seq ID No. 2.
A p75NTR neurotrophin binding protein (NBP)-Fc fusion protein according to claim 1, wherein the immunoglobulin Fc portion is Seq ID No. 3.
A p75NTR neurotrophin binding protein (NBP)-Fc fusion protein according to claim 1, wherein the immunoglobulin Fc portion is Seq ID No. 4.
A p75NTR neurotrophin binding protein (NBP)-Fc fusion protein according to claim 1, wherein the immunoglobulin Fc portion is Seq ID No. 5.
A p75NTR neurotrophin binding protein (NBP)-Fc fusion protein according to claim 1, wherein the immunoglobulin Fc portion is Seq ID No. 6
A p75NTR neurotrophin binding protein (NBP)-Fc fusion protein according to claim 1, wherein the linker portion is GGG.
A method of treating pain, wherein the method includes administering a therapeutic amount of a p75NTR neurotrophin binding protein (NBP)-Fc fusion protein, comprising:
- (a) p75NTR(NBP) portion with an amino acid sequence having at least 90% identity with a sequence selected from one of Seq ID No. 1 & 2;
- and
- (b) an immunoglobulin Fc portion with an amino acid sequence having at least 90% identity with a sequence selected from one of Seq ID No. 3-6;
- wherein, the p75NTR(NBP) and Fc portions are connected via a linker, the linker comprises a peptide of formula Gx, where x is 1, 2, 3, 4, 5 or 6 to a patient in need thereof.
A method according to claim 8, wherein the p75NTR(NBP) portion is Seq ID No. 2.
A method according to claim 8, wherein the immunoglobulin Fc portion is Seq ID No. 3.
A method according to claim 8, wherein the immunoglobulin Fc portion is Seq ID No. 4.
A method according to claim 8, wherein the immunoglobulin Fc portion is Seq ID No. 5.
A method according to claim 8, wherein the immunoglobulin Fc portion is Seq ID No. 6
A method according to claim 8, wherein the linker portion is GGG.
Dependencies are inferred from the claim text.