Degradation targeting agents and uses thereof

Abstract

Degradation targeting agents and uses thereof, such as for degrading proteins. The degradation targeting agents include a ligand moiety and a degradation targeting moiety. The degradation targeting moiety can include a degradation targeting peptide sequence that includes a C3HC4-type zinc-finger domain, such as a C3HC4-type zinc-finger domain from proteins such as helicase-like transcription factor (HLTF) and RO52. The ligand moiety can be a moiety that recruits the degradation targeting moiety to target molecules by binding to the target molecules. The degradation targeting agents can be used in methods of degrading target molecules by contacting the target molecules with the degradation targeting agents to induce degradation of the target molecules.

Dependencies are inferred from the claim text.