US 2026/0062441 A1 · TUMOR-SEEKING GLUCOSE-DENDRONS FOR THE DELIVERY OF CHEMOTHERAPEUTICS AND IMAGING AGENT TO CANCER CELLS

Abstract

The attachment of glucose to drugs and imaging agents enables cancer cell targeting via interactions with GLUT1 overexpressed on the cell surface. The present technology describes a biomimetic approach for the design of a multivalent glucose moiety (mvGlu). We showcase the utility of this new group by developing aza-BODIPY-based contrast agents boasting a significant PA signal enhancement greater than 11-fold after spectral unmixing. Moreover, when applied to targeting cancer cells, effective staining could be achieved with ultra-low dye concentrations (50 nM) and compared to a non-targeted analog, the signal intensity was >1000-fold higher. Also, we employed the mvGlu technology to develop a logic-gated acoustogenic probe to detect intratumoral Cu(I), which is an emerging cancer biomarker, in a murine model of breast tumor. This application was not possible using other acoustogenic probes previously developed for copper sensing.

Claims15

Dependent claims

A compound represented by Formula I:

wherein
G comprises a metalloid;
L1, L2, L3, and L4 are independently -PhJCH2R1, -PhR2, -Ph(R3)m, -Ph(R4)n, wherein Formula I includes at least one -PhJCH2R1;
J is O, S, or NRa;
Ra is each independently H, —(C1-C6)alkyl, or —(C3-C6) cycloalkyl;
R1 is a substituted triazole;
R2 is JCH2R1, H, halo, —(C1-C6)alkyl, —(C3-C6) cycloalkyl, —ORa, —SRa, or —N(Ra)2;
R3 and R4 are each independently H, halo, —(C1-C6)alkyl, —(C3-C6) cycloalkyl, —ORb, —SRb, —N(Rb)2, wherein Rb is H, —(C1-C6)alkyl, —(C1-C6)alkenyl, —(C1-C6)alkynyl, tris[(2-pyridyl)methyl]amine (TPA), or a metal coordination complex of TPA;
R5 and R6 are independently H, halo, —(C1-C6)alkyl, —(C3-C6) cycloalkyl, —ORa, —SRa, or —N(Ra)2;
and
m and n are independently 1, 2 or 3.

8 more elements

Dependencies are inferred from the claim text.

Tumor-seeking glucose-dendrons for the delivery of chemotherapeutics and imaging agent to cancer cells

Life of this patent

Tumor-seeking glucose-dendrons for the delivery of chemotherapeutics and imaging agent to cancer cells

Life of this patent

Abstract

Claims15