Back to results
US 2026/0062437 A1Published application
Antiviral compounds
AssigneeRegents of the University of Minnesota
InventorsDaniel Allen Harki, Samantha Anne Kennelly, Jacob Matthew Sawyer
Life of this patent
Estimating the term…
Abstract
The invention provides a compound of formula I: (I) or a salt thereof, wherein R1-R4 have any of the values described in the specification, as well as compositions comprising a compound of formula I. The compounds are useful as antiviral agents.
Claims26
A compound of formula I
- wherein:
- R1 is H, —P(═X)(OH)—O—P(═O)(OH)—P(═O)(OH)2, or —P(═X)(Ra)(Rb);
- R2 is H, F, Cl, Br, OH, (C1-C3)alkyl or (C1-C3)alkoxy, wherein any (C1-C3)alkyl and (C1-C3)alkoxy is optionally substituted with one or more halo;
- R3 is H, F, Cl, Br, OH, (C1-C3)alkyl or (C1-C3)alkoxy, wherein any (C1-C3)alkyl and (C1-C3)alkoxy is optionally substituted with one or more halo;
- R4 is selected from the group consisting of:
- Ra is an N-linked amino acid or a (C1-C6)alkyl ester of an N-linked amino acid, wherein the (C1-C6)alkyl is optionally substituted with phenyl;
- Rb is (C1-C6)alkoxy, aryloxy, or 5-10 membered heteroaryloxy, wherein any (C1-C6)alkoxy, aryloxy, and 5-10 membered heteroaryloxy is optionally substituted with one or more groups independently selected from the group consisting of halo, hydroxy, (C1-C3)alkoxy and (C1-C3)haloalkoxy;
- Rc is (C1-C3)alkyl, hydroxymethyl, formyl or carboxy;
- and
- X is S or O;
- or a salt thereof.
8 more elements
12-21. (canceled)
23-25. (canceled)
(canceled)
29-34. (canceled)
36-38. (canceled)
A compound selected from the group consisting of:
- or a salt thereof.
A compound selected from the group consisting of:
- or a salt thereof.
44-46. (canceled)
Dependencies are inferred from the claim text.