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AssigneeRexpharmtech Co., Ltd
InventorsJi Seok YOO, Yongnam LEE, Jong Hun LEE, Ju Young BAEK, Dae Hyeon KIM
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The present invention relates to a novel benfotiamine choline salt, a preparation method thereof, and a use thereof. A benfotiamine choline salt according to the present invention has excellent stability and significantly higher water solubility compared to conventional benfotiamine, thus exhibiting improved dissolution and bioavailability. In addition, a benfotiamine choline salt according to the present invention is effective to improve cognitive functions or to prevent or treat cranial nerve diseases, and thus it can be usefully applied as a pharmaceutical raw material or health functional food raw material.
A benfotiamine choline salt of Formula 1 below:
A benfotiamine choline salt crystalline form comprising diffraction peaks at 2θ values of 5.39±0.2°, 8.86±0.2°, 10.59±0.2°, 13.12±0.2°, 15.46±0.2°, 18.11±0.2°, 18.51±0.2°, 22.36±0.2°, 26.16±0.2°, and 30.98±0.2° in powder X-ray diffraction.
A method for preparing a benfotiamine choline salt, the method comprising reacting benfotiamine with choline hydroxide.
A method for preparing a benfotiamine choline salt, the method comprising:
Dependencies are inferred from the claim text.