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US 2026/0062431 A1Published application
Silicon-incorporated hdac-6 inhibitor for liver and lung fibrotic disorder
OwnerDumbala Srinivasa REDDY, Sai Balaji ANDUGULAPATI +5inventors
InventorsDumbala Srinivasa REDDY, Sai Balaji ANDUGULAPATI, Laxman Devappa NANDAWADEKAR, Ramesh EAGALA, Nidhi SHARMA, Ganesh ROUTHOLLA, Hari Priya SRIPADI
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Abstract
The present invention discloses silicon-incorporated HDAC-6 inhibitors of formula (I) and the process of preparation thereof. The invention further relates to methods of treating a group consisting of idiopathic pulmonary fibrosis, hepatic fibrosis, and other fibrotic disorders such as cardiac, kidney, and skin fibrosis.
Claims17
A silicon-incorporated HDAC 6 inhibitor compound of formula (I)
- wherein,
- n is selected from 0-4;
- R1 is selected from the group consisting of hydrogen, halogen, C1-C5 alkyl, C1-C5 alkoxy;
- R2 and R5 are independently selected from the group consisting of C1-C3 alkyl, aryl groups;
- R4 is selected from the group consisting of hydroxy, NH2, C1-C12 alkyl amine, substituted aryl amine and a mixture thereof.
2 more elements
Dependencies are inferred from the claim text.