Solid state forms of risdiplam and process for preparation thereof
AssigneeAssia Chemical Industries Ltd.
InventorsSanja Matecic Musanic, Dario Klaric, Mateja Kolenic
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Abstract
The present disclosure encompasses solid state forms of Risdiplam, including crystalline polymorphs of Risdiplam, processes for preparation thereof, and pharmaceutical compositions thereof.
Claims19
A process for preparing a crystalline form 3 of Risdiplam, the process comprising converting a crystalline form 2 of Risdiplam into the crystalline form 3 of Risdiplam by drying under thermal or vacuum conditions, and isolating the crystalline form 3 of Risdiplam.
A process for preparing a crystalline form 2 of Risdiplam, the process comprising crystallizing the crystalline form 2 of Risdiplam under conditions selected from suspension in water, dissolution in ethanol followed by addition of water, or exposure to humidity, and isolating the crystalline form 2 of Risdiplam.
Dependencies are inferred from the claim text.