Solid forms of posiphen d-tartrate

A solid form of crystalline (3aR)-1, 3a, 8-trimethyl-1, 2, 3, 3a, 8, 8a-hexahydropyrrolo (2, 3-b) indol-5-yl phenyl-carbamate tartrate dihydrate (posiphen D-tartrate Form B), characterized by an X-ray powder diffraction pattern having the following characteristic peaks, relative intensities, and d-spacing values:

• Diffraction
• Relative
• d-spacing
• Angle 2θ
• Intensity %
• Value (Å)
• 5.16
• 100
• 17.13
• 8.56
• 10
• 10.33
• 10.3
• 13
• 8.59
• 11.24
• 14
• 7.87
• 13.14
• 17
• 6.74
• 13.48
• 6
• 6.57
• 14.66
• 11
• 6.04
• 15.24
• 28
• 5.81
• 15.44
• 12
• 5.74
• 15.76
• 14
• 5.62
• 16.18
• 29
• 5.48
• 16.54
• 9
• 5.36
• 17.48
• 24
• 5.07
• 17.94
• 9
• 4.94
• 18.08
• 63
• 4.91
• 19.72
• 51
• 4.50
• 20.62
• 19
• 4.31
• 20.76
• 9
• 4.28
• 21.22
• 9
• 4.19
• 21.5
• 17
• 4.13
• 22.2
• 8
• 4.00
• 22.54
• 19
• 3.94
• 23.46
• 17
• 3.79
• 24.4
• 9
• 3.65
• 24.72
• 5
• 3.60
• 26.4
• 15
• 3.38
• 26.86
• 10
• 3.32
• 27.14
• 10
• 3.29
• 27.48
• 6
• 3.25
• 27.7
• 15
• 3.22
• 28.52
• 10
• 3.13
• 28.74
• 5
• 3.11
• 29.14
• 6
• 3.06
• 29.96
• 14
• 2.98
• 30.68
• 6
• 2.91
• 31.14
• 9
• 2.87
• 32.3
• 5
• 2.77
• 33.26
• 5
• 2.69
• 35.44
• 7
• 2.53
• 37.24
• 5
• 2.41
• 37.74
• 5
• 2.38.

A method of treating Alzheimer's disease in a subject in need thereof, comprising orally administering to the subject an effective amount of a pharmaceutical composition comprising a solid form of (3aR)-1, 3a, 8-trimethyl-1, 2, 3, 3a, 8, 8a-hexahydropyrrolo (2, 3-b) indol-5-yl phenyl-carbamate tartrate dihydrate (posiphen D-tartrate Form B) and a pharmaceutically acceptable carrier;

• wherein the solid form of (3aR)-1, 3a, 8-trimethyl-1, 2, 3, 3a, 8, 8a-hexahydropyrrolo (2, 3-b) indol-5-yl phenyl-carbamate tartrate dihydrate:
• a) is characterized by an X-ray powder diffraction pattern having characteristic peaks at 5.16, 8.56, 10.3, 11.24, 13.14, 13.48, 14.66, 15.24, 15.44, 15.76, 16.18, 16.54, 17.48, 17.94, 18.08, 19.72, 20.62, 20.76, 21.22, 21.5, 22.2, 22.54, 23.46, 24.4, 24.72, 26.4, 26.86, 27.14, 27.48, 27.7, 28.52, 28.74, 29.14, 29.96, 30.68, 31.14, 32.3, 33.26, 35.44, 37.24, and 37.74 in 2θ;
• or
• b) is characterized by an X-ray powder diffraction pattern having the following characteristic peaks, relative intensities, and d-spacing values:
• Diffraction
• Relative
• d-spacing
• Angle 2θ
• Intensity %
• Value (Å)
• 5.16
• 100
• 17.13
• 8.56
• 10
• 10.33
• 10.3
• 13
• 8.59
• 11.24
• 14
• 7.87
• 13.14
• 17
• 6.74
• 13.48
• 6
• 6.57
• 14.66
• 11
• 6.04
• 15.24
• 28
• 5.81
• 15.44
• 12
• 5.74
• 15.76
• 14
• 5.62
• 16.18
• 29
• 5.48
• 16.54
• 9
• 5.36
• 17.48
• 24
• 5.07
• 17.94
• 9
• 4.94
• 18.08
• 63
• 4.91
• 19.72
• 51
• 4.50
• 20.62
• 19
• 4.31
• 20.76
• 9
• 4.28
• 21.22
• 9
• 4.19
• 21.5
• 17
• 4.13
• 22.2
• 8
• 4.00
• 22.54
• 19
• 3.94
• 23.46
• 17
• 3.79
• 24.4
• 9
• 3.65
• 24.72
• 5
• 3.60
• 26.4
• 15
• 3.38
• 26.86
• 10
• 3.32
• 27.14
• 10
• 3.29
• 27.48
• 6
• 3.25
• 27.7
• 15
• 3.22
• 28.52
• 10
• 3.13
• 28.74
• 5
• 3.11
• 29.14
• 6
• 3.06
• 29.96
• 14
• 2.98
• 30.68
• 6
• 2.91
• 31.14
• 9
• 2.87
• 32.3
• 5
• 2.77
• 33.26
• 5
• 2.69
• 35.44
• 7
• 2.53
• 37.24
• 5
• 2.41
• 37.74
• 5
• 2.38.