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US 2026/0062407 A1Published application
Peroxiredoxin 3 inhibitors and methods of use for treating cancer
AssigneeWake Forest University Health Sciences
InventorsW. Todd LOWTHER, Terrence L. SMALLEY, Kimberly J. NELSON
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Abstract
Provided according to some embodiments is a compound of Formula (1), a 2-aryl, 2-heteroaryl, 2-cycloalkyl or 2-heterocycle substituted thiazole-4-carboxamido) acrylamido)acrylate compound, as a peroxiredoxin 3 (PRX3) inhibitor, or a pharmaceutically acceptable salt or prodrug thereof. Pharmaceutical compositions comprising the same and methods of use for treating cancer and inhibiting PRX3 in a subject in need thereof, are also provided.
Claims29
A compound of Formula I:
- wherein R1 is an aryl, heteroaryl, cycloalkyl or heterocycle, which aryl, heteroaryl, cycloalkyl or heterocycle is optionally substituted with one or more selected from alkyl, carboxy, carbamate, urea, amide, amino, ether, ester and halo;
- and
- wherein when R1 is pyridine or pyrazine, said pyridine or pyrazine is substituted with one or more selected from alkyl, carboxy, carbamate, urea, amide, amino, ether, ester and halo,
- or a pharmaceutically acceptable salt thereof.
1 more element
Dependencies are inferred from the claim text.