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US 2026/0062401 A1Published application
Methods of treating neurological disorders
AssigneeNeumora Therapeutics, Inc.
InventorsPaul Dransfield, Dilinie Fernando, James Harvey, Brian Sparling, John Stellwagen, Zhihua Ma, Anne-Marie Beausoleil, Ryan Hudson
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Abstract
The present disclosure relates to compounds of Formula (I), and pharmaceutically acceptable salts thereof, wherein the variable are as described herein, and compositions and uses of same for treating neurological disorders.
Claims24
A compound of Formula (I),
- or a pharmaceutically acceptable salt thereof, wherein:
- R1 is hydrogen or C1-C6 alkyl;
- R2 is C1-C8 alkyl, C1-C8 haloalkyl, C3-C8 cycloalkyl, or —NRARB;
- RA and RB are independently hydrogen or C1-C6 alkyl, or RA and RB together with the nitrogen atom to which they are attached form a 4-6 membered heterocyclyl;
- each R3 is independently halogen, cyano, hydroxyl, or C1-C6 alkyl;
- X is CH, CR3, or N;
- R4 is chloro, cyano, hydroxyl, or trifluoromethyl;
- each R5 is independently halogen, cyano, hydroxyl, C1-C6 alkyl, or C1-C6 haloalkyl;
- and
- m and n are independently 0, 1, 2, or 3.
7 more elements
(canceled)
-11. (canceled)
-17. (canceled)
-24. (canceled)
(canceled)
Dependencies are inferred from the claim text.