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US 2026/0062393 A1Published application
Compounds
AssigneeCtxt Pty Ltd
InventorsH. Rachel Lagiakos, Benjamin Joseph Morrow, Richard Charles Foitzik, Catherine Fae Hemley, Michelle Ang Camerino, Paul Anthony Stupple, Ylva Elisabet Bergman Bozikis, Scott Raymond Walker
Life of this patent
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Abstract
A compound of formula (1), or a pharmaceutical salt thereof:
Claims20
A compound of formula (I), or a pharmaceutically acceptable salt thereof:
- wherein:
- R1, R2, R3 and R4 are independently selected from the group consisting of:
- (i) H;
- (ii) C1-3 alkyl, optionally substituted by:
- hydroxy,
- C1-2 alkoxy, optionally substituted by one or more fluoro groups,
- NH2,
- phenyl,
- C5-6 heteroaryl,
- C1-4 alkyl carbamoyl,
- acylamido, or
- one or more fluoro groups;
- (iii) C1-3 alkoxy, optionally substituted by C3-6 cycloalkyl or by one or more fluoro groups;
- (iv) C3-6 cycloalkyl;
- (v) halo;
- (vi) CORC, where RC is selected from NRN1RN2, where RN1 and RN2 are independently selected from H and methyl;
- (vii) cyano, NH2, or NO2;
- and
- (viii) phenyl or C5-6 heteroaryl, optionally substituted by methyl, cyano, hydroxy or methoxy;
- Ar is selected from the group consisting of:
- (a) 5-ethyl-2-methoxyphenyl;
- (b) 5-CF3-2-methoxyphenyl;
- and
- (c) 2,6-dimethoxyphenyl.
21 more elements
A method of treating cancer comprising administering to a patient in need of treatment a compound of formula (I), or a pharmaceutically acceptable salt thereof:
- wherein:
- R1, R2, R3 and R4 are independently selected from the group consisting of:
- (i) H;
- (ii) C1-3 alkyl, optionally substituted by:
- hydroxy,
- C1-2 alkoxy, optionally substituted by one or more fluoro groups,
- NH2,
- phenyl,
- C5-6 heteroaryl,
- C1-4 alkyl carbamoyl,
- acylamido, or
- one or more fluoro groups;
- (iii) C1-3 alkoxy, optionally substituted by C3-6 cycloalkyl or by one or more fluoro groups;
- (iv) C3-6 cycloalkyl;
- (v) halo;
- (vi) CORC, where RC is selected from NRN1RN2, where RN1 and RN2 are independently selected from H and methyl;
- (vii) cyano, NH2, or NO2;
- and
- (viii) phenyl or C5-6 heteroaryl, optionally substituted by methyl, cyano, hydroxy or methoxy;
- Ar is selected from the group consisting of:
- (a) 5-ethyl-2-methoxyphenyl;
- (b) 5-CF3-2-methoxyphenyl;
- and
- (c) 2,6-dimethoxyphenyl.
21 more elements
Dependencies are inferred from the claim text.