Kv7 channel activators compositions and methods of use

A method of treating substance abuse comprising administering to a subject in need of such treatment a therapeutically effective amount of a compound represented by Formula 11:

• wherein
• D is optionally substituted C2-5 alkyl or optionally substituted phenyl, wherein the optional substituents are selected from —CH3 and F;
• A is C1-6 alkyl;
• X is H, F, —CH3, —CF3, —SCF3, pyridinyl, optionally substituted C1-3 alkyl, optionally substituted phenyl, or optionally substituted cyclobutyl, wherein the optional substituent is F;
• Y is H, F, —OH, or —CH3;
• R1 is H, C3-4 hydroxyalkyl, —CN, —OH, —CF3, —OCHF2, optionally substituted C3-5 heterocyclyl, optionally substituted C1-5 alkyl, optionally substituted C1-7 alkoxy, —NRARB, or halogen, wherein the optional substituents are selected from —OH and F;
• R2 is H, halogen, —CN, —OCH3, —CORA, —CF3, —OCF3, optionally substituted C1-2 alkyl, wherein the optional substituents of R2 are selected from —OCH3 and —CORA;
• R3 is H, halogen, —CF3, —OCHF2, —OCF3, or —OCH3;
• R4 is H, halogen, or C3 hydroxyalkyl;
• and
• RA and RB are CH3;
• or a pharmaceutically acceptable salt thereof.