Material and method for performing a separation based on halogen bonding
AssigneeMerck Patent GmbH
InventorsBerthold Theo HOGE, Paul Lukas WALTERSMANN, Anne Julia BADER
Life of this patent
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Abstract
This invention relates to a new stationary phase carrying functional groups comprising a halogen substituted aromatic ring. Target molecules can interact with this stationary phase by halogen bonding. The stationary phase is suitable for SPE or chromatographic separations.
Claims16
A stationary phase comprising a base material and at least one type of functional group, the functional group is covalently bonded to the base material, wherein the functional group is a positively charged heterocyclic aromatic group carrying at least one Cl, Br, or I residue according to:
- with R′ being H or C1-C6 alkyl, EW being independent of each other H or an electron withdrawing group, and Hal being Cl, Br, or I;
- with one R/L being H or C1-C6 alkyl and the other R/L being connected to the base material, EW being H, or an electron withdrawing group, and Hal being Cl, Br, or I;
- or
- (c) a structure according to:
- with X′ and X″ being independently of each other H, an electron withdrawing group, or an electron donating group, and R being H, an electron withdrawing group, or an electron donating group, and whereby at least one X or X′ is Cl, Br or I.
A stationary phase comprising a base material and at least one type of functional group, the functional group is covalently bonded to the base material, wherein the functional group is a positively charged heterocyclic aromatic group carrying at least one Cl, Br, or I residue according to:
- whereby one atom A of the aromatic ring, which is not the one providing for connection to the base material, is O+ or S+ and the other ring atoms A are C—X′, with X′ being independently of each other H, I, Br, Cl, or an electron withdrawing group, aryl or an electron donating group, whereby at least one X′ is Cl, Br or I;
- or
- with R′ being H or C1-C6 alkyl,
- EW being independent of each other H or an electron withdrawing group,
- and Hal being independent of each other H, CH3, Cl, Br or I, whereby at least one Hal is Cl, Br or I.
Dependencies are inferred from the claim text.