Applicator for a microneedle array patch delivery system

An applicator for applying a medicament patch to a subject comprising:

• a top portion configured to be pressed downwards to activate an activation mechanism;
• a bottom portion holding the medicament patch such that the medicament patch is suspended above a skin surface of the subject;
• a middle portion connected to the top portion and the bottom portion, the middle portion comprising one or more elastic members configured to contribute about 6-15 lbs to an activation force of the activation mechanism;
• a piston portion connected to the middle portion;
• and
• a compressible member positioned between the middle portion and the piston portion;
• wherein when the activation mechanism is activated, the piston portion is released from the top portion and the middle portion and moves downwards via force applied by the compressible member;
• wherein, when the piston portion moves downwards, the medicament patch is released from the bottom portion and pushed downward by the piston portion directly contacting the medicament patch onto the skin surface of the subject.

An applicator for applying a medicament patch to a subject comprising:

• a top portion configured to be pressed downwards to activate an activation mechanism;
• a bottom portion holding the medicament patch such that the medicament patch is suspended above a skin surface of the subject;
• a middle portion connected to the top portion and the bottom portion;
• a piston portion connected to the top portion and the middle portion and comprising a domed-piston face comprising a dome radius of at least about 20 mm;
• and
• a compressible member positioned between the middle portion and the piston portion;
• wherein when the activation mechanism is activated, the piston portion is released from the top portion and the middle portion and moves downwards via force applied by the compressible member;
• wherein, when the piston portion moves downwards, the medicament patch is released from the bottom portion and pushed downward by the piston portion directly contacting the medicament patch onto the skin surface of the subject.