Lipid analogs, liposomes comprising same and uses thereof

A polymeric compound represented by Formula I:

• wherein:
• m is zero or a positive integer;
• n is an integer which is at least 2, at least 5, preferably at least 10 (e.g., of from 10 to 200);
• Y is a backbone unit which forms a polymeric backbone of the polymeric compound;
• L is absent or is a linking moiety;
• and
• Z has the general Formula II:
• wherein:
• the dashed (curved) line denotes an attachment point to the respective Y backbone unit or to the linking moiety L, if present;
• A is a substituted or unsubstituted hydrocarbon;
• B is an oxygen atom or is absent;
• R1-R3 are each independently selected from the group consisting of hydrogen, alkyl, cycloalkyl, heteroalicyclic, aryl and heteroaryl;
• X is a lipid moiety represented by Formula IV:
• wherein:
• the dashed (curved) line denotes an attachment point to said polymeric backbone;
• F1, F2, F3 and F4 are each independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, acyl, alkoxy, thioalkoxy, carboxy, thiocarboxy, wherein at least one of F1, F2, F3 and F4 is not hydrogen and is of at least 10 carbon atoms in length;
• J is —O—P(═O)(OH)—O— or absent;
• K is a substituted or unsubstituted hydrocarbon from 1 to 10 carbon atoms in length or absent;
• M is a linking group selected from the group consisting of —O—, —S—, amino, sulfinyl, sulfonyl, phosphate, phosphonyl, phosphinyl, carbonyl, thiocarbonyl, urea, thiourea, carbamyl, thiocarbamyl, amido, carboxy, and sulfonamide, or absent;
• and
• Q is a substituted or unsubstituted hydrocarbon from 1 to 10 carbon atoms in length, or absent,
• wherein when M is absent, Q is also absent, and when J is absent, M is not absent,
• provided that:
• when J is —O—P(═O)(OH)—O—, M is other than amido and/or Q comprises an aryl moiety.