Methods and compositions of treating retinal degenerative diseases
AssigneeCity University of Hong Kong
InventorsWenjun XIONG, Zhifei WU, Baoshan LIAO
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Abstract
A method for treating retinal degenerative diseases in a subject, which involves administering an agonist to selectively elevate cyclin D1 expression in Müller glia (MG) cells, and administering an antagonist to selectively knock down p27Kip1 expression in MG cells.
Claims20
A method of treating retinal degenerative diseases in a subject in need thereof, comprising:
- administering an agonist selectively elevates the expression of cyclin D1 in Müller glia (MG) cells;
- and
- administering an antagonist selectively knocks down the expression of p27kip1 in MG cells.
A composition for treating retinal degenerative diseases in a subject in need thereof, comprising an agonist selectively elevates the expression of cyclin D1 in MG cells, an antagonist selectively knocks down the expression of p27kip1 in MG cells and a pharmaceutically acceptable addition.
Dependencies are inferred from the claim text.