Compositions and methods for tunable magnetic nanoparticles
AssigneeThe General Hospital Corporation
InventorsMehmet V. Yigit, Zdravka Medarova, Byunghee Yoo, Eli Mattingly
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Abstract
The present disclosure presents nanoparticle compositions for use in the treatment, prevention, or imaging of a disease (e.g., cancer), methods of treating, preventing, or imaging a disease in a subject in need thereof with the nanoparticle compositions, and methods of preparing the nanoparticle compositions of the disclosure. The nanoparticle compositions can include a magnetic nanoparticle ferric chloride, ferrous chloride, or a combination thereof, and a dextran coating functionalized with one or more amine groups.
Claims12
1-31. (canceled)
A pharmaceutical composition comprising:
- a magnetic nanoparticle comprising an iron oxide core;
- a dextran coating functionalized with a number of surface amine groups from about 30 to about 150;
- one or more oligonucleotides covalently attached to the surface amine groups;
- and
- at least one pharmaceutically acceptable carrier or diluent,
- wherein the composition comprises an iron concentration of about 1 mg/ml to about 15 mg/ml and has a polydispersity index (PDI) of about 0.050 to 0.100.
-42. (canceled)
Dependencies are inferred from the claim text.