Compositions including sbi adjuvants and methods of use thereof

A method of making a fusion polyribonucleotide comprising the steps of:

• (i) recombinantly joining a first nucleotide sequence that encodes a fragment antigen, an antigen variant, or a fragment antigen variant, that comprises at least one epitope of a target protein antigen, and a second nucleotide sequence that encodes a complement C3d-binding polypeptide from a immunoglobulin-binding protein (Sbi) of Staphylococcus aureus to form a fusion polynucleotide comprising the first nucleotide sequence and the second nucleotide sequence, and
• (ii) using the fusion polynucleotide of (i) in an in vitro transcription reaction to make a fusion polyribonucleotide.