Method for prevention and treatment of viral disease

A method for reducing viral load resulting from a viral infection in a subject in need thereof, comprising:

• administering to the subject in need thereof an effective amount of a pharmaceutical composition comprising a hybrid protein comprising a first domain comprising a sequence encoding an ectodomain of a trimeric surface protein of an enveloped RNA virus and a second domain comprising a sequence encoding an ectodomain of a type 2 transmembrane domain protein, wherein the second domain is located at the C-terminal of the first domain;
• and
• a pharmaceutically acceptable carrier.

A method for increasing immunity to viral infection in a subject in need thereof, comprising:

• administering to the subject in need thereof an effective amount of a pharmaceutical composition comprising a hybrid protein comprising a first domain comprising a sequence encoding an ectodomain of a trimeric surface protein of an enveloped RNA virus and a second domain comprising a sequence encoding an ectodomain of a type 2 transmembrane domain protein, wherein the second domain is located at the C-terminal of the first domain;
• and
• a pharmaceutically acceptable carrier.