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AssigneesUniversity of Oregon, Georgia Tech Research Corporation
InventorsNick Willett, Elaine deLorimier, Edward Botchwey, Thomas Turner
Estimating the term…
Methods of stimulating production of specialized pro-resolving mediators (SPMs) by mesenchymal stem cells (MSCs) are provided. The methods include contacting MSCs with one or more SPM fatty acid precursors, SPM intermediates, or a combination of two or more thereof. Also provided are compositions including the stimulated MSCs or conditioned media from the stimulated MSCs. Methods of treating or inhibiting inflammation are also provided, including administering to a subject stimulated MSCs or conditioned media from stimulated MSCs.
A method of stimulating or increasing production of one or more specialized pro-resolving mediators (SPMs) by mesenchymal stromal cells (MSCs), comprising contacting a population of MSCs with one or more SPM fatty acid precursors or SPM intermediates, or a combination of two or more thereof,
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A method of treating or inhibiting inflammation in a subject, comprising administering to the subject:
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The method of claim 12, wherein the subject has inflammation from a musculoskeletal disorder or injury, or a dermal injury.
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Dependencies are inferred from the claim text.