Compounds for the Prevention and Treatment of Medical Disorders and Uses Thereof

A compound of Formula II or a pharmaceutically acceptable salt or solvate thereof:

• Formula II:
• wherein A-M is a 2 atoms linkage having the structure of an amide —N(—Ra)—C(═O)—, sulfonamide —N(—H)—S(═O2)-, a methylether —C(—H2)-O—, methylester —C(═O)—O—, carbosulfon —C(—H2)—S(═O)(═O)—, phosphate —O—P(═O)(—OH)—, diphosphate —O—P(═O)(—O)—O—P(═O)(—O)—, Hydrazide —N(—H)—N(—H)—, selanomethylene, ethylene, or glycol,
• wherein linkage (Y) is (—CH═) or (—CH2-) or —CH2-X—,
• wherein X is nitrogen, oxygen, sulfur or selenium;
• wherein Z is a carbon, or a heteroatom wherein the heteroatom is nitrogen, oxygen sulphur, or selenium;
• wherein R1 is hydrogen, oxygen, amine, carboxyl, C1-C6 alkyl, C1-C4 alkoxy, aryl, halogen, trifluoromethyl, dinitromethyl or a combination of the foregoing;
• and
• wherein R2 and R3 are independently selected from the group consisting of hydrogen, hydroxyl, amine, C1-C6 alkyl, C1-C4 alkoxy, and halogen;
• or wherein R2, R3 or R2 and R3 are aryl group with one or more substitutions, wherein the one or more substitutions is hydroxyl, amine, C1-C6 alkyl, C1-C4 alkoxy, halogen, or benzene;
• or wherein R2, R3 or R2 and R3 are fluoromethyl.

A compound of Formula IV or a pharmaceutically acceptable salt or solvate thereof:

• Formula IV:
• wherein Z is a carbon, or a heteroatom wherein the heteroatom is nitrogen, oxygen Sulphur, or selenium;
• wherein R1, R2, R3 and R4 are independently selected from the group consisting of CO, SO2, SO, PO2, PO, CH, Hydrogen, hydrophobic linear and cyclic hydrocarbons including heterocyclic substitutions of molecular weight of about 10-200 D;
• wherein linkage (Y) is methylidene (—CH═) or methylene (—CH2-)—) or —CH2-X—;
• wherein X is nitrogen, oxygen, sulfur or selenium;
• and
• wherein the A-M linkage being at least 2 atoms linkage having the structure of an amide —N(—Ra)—C(═O)—, sulfonamide —N(—H)—S(═O2)-, a methylether —C(—H2)-O—, methylester —C(═O)—O—, carbosulfon —C(—H2)-S(═O)(═O)—, phosphate —O—P(═O)(—OH)—, diphosphate —O—P(═O)(—O)—O—P(═O)(—O)—, Hydrazide —N(—H)—N(—H)—, selanomethylene, ethylene, or glycol.