Quantitative Method of Determining a Mental Status Based on DRD1 and/or DRD5, and its Application Thereof

A method of treatment of mental disorder of a subject, comprising the steps of:

• bidirectionally normalizing an overall expression level of DRD1, DRD5, or DRD1 and DRD5 of the subject to a preset standard level.

A quantitative screening method of mental disorder of a subject, comprising the steps of:

• carrying out genomic sequencing of DRD1 and DRD5 genes (including 7-kb 5′-upstream sequence, protein coding sequence, and 2-kb 3′-downstream sequence) of a plurality of subjects to establish a relationship between a mental disorder and a variant distribution database (including a type, a location and a frequency of each gene variant) in the DRD1 and DRD5 genes;
• sorting out one or more variant that is highly related to one mental disorder to develop a target gene sequence of DRD1 and DRD5 genes, which can be used to determine a risk of developing the mental disorder;
• performing the target gene sequence of DRD1 and DRD5 genes in a target subject to determine the risk of developing the mental disorder in the target subject.

The quantitative screening method of mental disorder of a subject, wherein more than two variants are related to one mental disorder.

A quantitative method of screening new medications of mental disorder, comprising the steps of:

• bidirectionally normalizing an overall expression level of DRD1 and/or DRD5 of the subject to a preset standard level,
• wherein the mental disorder comprises schizophrenia, autism, depression, mania and bipolar disorders,
• wherein the sample sequence comprises at least one variations when compared to the standard sequence database.