Formulations with reduced oxidation
AssigneeGenentech, Inc.
InventorsSreedhara ALAVATTAM, Mary MALLANEY, Parbir GREWAL
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Abstract
The invention provides formulations comprising a protein in combination with a compound that prevents oxidation of the protein. The invention also provides methods for making such formulations and methods of using such formulations. The invention further provides methods of screening for compounds that prevent oxidation of a protein in a protein composition and methods of preventing oxidation of a protein in a formulation.
Claims13
-42. (canceled)
A liquid formulation comprising an antibody and a compound which prevents oxidation of the antibody in the liquid formulation, wherein the compound is of formula:
- wherein R2 and R3 are independently selected from hydrogen, hydroxyl, —COOH, and —CH2COOH;
- R4, R5, R6, and R7 are independently selected from hydrogen and hydroxyl;
- provided that one of R2, R3, R4, R5, R6, and R7 is hydroxyl;
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.