eNAMPT INCREASING AGENT, SIRTUIN ACTIVATION OR EXPRESSION ENHANCER, NAD+ INCREASING AGENT, AND SENESCENT CELL INHIBITOR

A method of increasing extracellular nicotinamide phosphoribosyltransferase (eNAMPT) levels in an animal, the method comprising administering to the animal an effective amount of an agent comprising S-1-propenylcysteine, or a salt thereof.

A method of increasing nicotinamide mononucleotide (NAD+) levels in a cell, tissue or organ in an animal, the method comprising administering to the animal an effective amount of an agent comprising S-1-propenylcysteine, or a salt thereof.

A method of treating an injury, disorder or disease in an animal, wherein the injury, disorder or disease is selected from the group consisting of one, or more of:

• kidney injury or disease, cognitive/memory disorders of the brain, liver disease, skeletal muscle disease or heart disease, the method comprising administering to the animal an effective amount of an agent comprising S-1-propenylcysteine, or a salt thereof, resulting in increased levels of one, two or all of eNAMPT, NAD+, or sirtuins, in the animal, thereby treating the disease or disorder in the animal.