Nuclear receptor subfamily 4 group a agonists and methods of use for treatment of infectious diseases

A method for treating a patient with an infectious or an inflammation-related disease, comprising:

• administering a therapeutically effective amount of N-(3-acetylphenyl)-5,6,7,8-tetrahydronaphthalene-2-carboxamide (available at Life Chemicals as F0537-0485) or a pharmaceutically acceptable salt or derivative thereof.

A method for treating a patient with an infectious or an inflammation-related disease, comprising:

• administering a therapeutically effective amount of one of N-[(1-hydroxy-2,3-dihydro-1H-inden-1-yl)methyl]naphthalene-1-carboxamide (available at Life Chemicals as F5857-5371), 3,4-difluoro-N-[(2-hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)methyl]benzamide (available at Life Chemicals as F6414-1064), N-(3-hydroxy-3-phenylpropyl)naphthalene-1-carboxamide (available at Life Chemicals as F5857-6887), N-(2-hydroxy-3-phenylpropyl)naphthalene-1-carboxamide (available at Life Chemicals as F6200-1091) or a pharmaceutically acceptable salt or derivative thereof.

A method for treating a patient with an infectious or an inflammation-related disease, comprising:

• administering a therapeutically effective amount of one or more of F5964-0242, F5964-0253, F1065-0517, F0020-1803, F5857-5401, F0915-2916, F0307-0288, F3350-0754, F6172-0216, F3367-0092, F6172-0224, F5857-2441, F5857-6404, and F5857-5470 (available at Life Chemicals) or a pharmaceutically acceptable salt thereof.