Device for maintaining metal homeostasis, and uses thereof

Method for extracting metal cations from a biological fluid of a subject in need thereof, comprising dialyzing said subject with a dialysis device, said dialysis device comprising:

• a porous dialysis membrane, and
• a reservoir containing a perfusion fluid which comprises at least one chelator:
• said at least one chelator being grafted on polymers, or
• said at least one chelator being grafted on nanoparticles, wherein the cut-off threshold of the porous membrane is lower than the mass of the polymer or the nanoparticle to which the at least one chelator is grafted, and wherein said metal cations from a biological fluid of a subject are extracted by complexing to said chelator during dialysis.