System and method to reduce tissue organ adhesion

Abstract

A composition for providing a barrier between tissues and/or organs during or after a surgical procedure. The composition is a flowable solution of a hydrophobically-modified chitosan, wherein the hydrophobic modifications are selected to allow for adherence to tissue, cohesiveness of the composition upon application to tissue, and degradation over about two weeks after application. A method for providing a barrier between tissues and/or organs during or after a surgical procedure. Applying a hydrophobically-modified polymer to surfaces of tissues or organs in within a surgical site either before, during, and/or after a surgical procedure, wherein the modified polymer reduces adhesion between organs or tissues after surgery.

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