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US 2026/0048073 A1Published application
Toll-like receptor 4 (tlr4) agonist and methods of use thereof
AssigneeNanyang Technological University
InventorsYuan QIAO, Chenyu LI, Christopher William Emmanuel ADAMSON
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Abstract
The present invention relates generally to the field of immunomodulation and more specifically to compounds that exhibit Toll-like receptor 4 (TLR4) agonist activity. The invention provides novel compounds capable of stimulating or promoting an immune response, thereby offering potential therapeutic applications. In particular, the compounds may be useful in methods of promoting and/or maintain gastrointestinal health, as well as treating or preventing gastrointestinal diseases, such as IBD and colitis.
Claims20
A Toll-Like Receptor 4 (TLR4) agonist having a formula (I):
- wherein
- n is an integer number selected from 1-4, and
- R1, R2, R3, R4, R5, R6, R7 independently selected from the group consisting of —H, —OH, —NHC(O)Me, —OC(CH3)COOH, —NH2, and —OP(O)(OH)2,
- or a pharmaceutically acceptable salt, stereoisomeric form, or regioisomeric form thereof.
1 more element
Dependencies are inferred from the claim text.