Polymorphs of co-crystals of itanapraced and nicotinamide
AssigneeCereSpir Incorporated
InventorsDaniel Chain, Matt Forster, Richard Margolin, Ronald Mueller
Life of this patent
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Abstract
Polymorphs of co-crystals of itanapraced and nicotinamide and pharmaceutical compositions and dosage forms containing the polymorphs are described. Methods of synthesizing the polymorphs and uses of polymorphs are also described.
Claims20
A polymorph of a co-crystal of itanapraced and nicotinamide, the polymorph comprising a crystal lattice comprising itanapraced and nicotinamide in a stoichiometric ratio of about 1:1, wherein the polymorph has an X-ray Powder Diffraction Pattern (XRPD) having at least five peaks at positions selected from the group consisting of 17.8°, 5.7°, 18.2°, 17.1°, 37.0°, 28.6°, 14.2°, 31.5°, 22.8°, 13.9°, 25.7°, 35.9°, 22.3°, 19.7°, 29.0°, 37.4°, 39.8°, 15.1°, 29.5°, 20.1°, 11.4°, 24.1°, 8.5°, 16.5°, and 33.2°, expressed in 2θ, produced from a Cu radiation source (λ=1.54 Å after Ni filtering).
A crystalline system comprising itanapraced and nicotinamide in a crystal lattice, wherein the crystalline system has an X-ray Powder Diffraction Pattern (XRPD) having at least five peaks at positions selected from the group consisting of 17.8°, 5.7°, 18.2°, 17.1°, 37.0°, 28.6°, 14.2°, 31.5°, 22.8°, 13.9°, 25.7°, 35.9°, 22.3°, 19.7°, 29.0°, 37.4°, 39.8°, 15.1°, 29.5°, 20.1°, 11.4°, 24.1°, 8.5°, 16.5°, and 33.2°, expressed in 2θ, produced from a Cu radiation source (λ=1.54 Å after Ni filtering).
A crystalline system comprising itanapraced and nicotinamide in a crystal lattice and in a stoichiometric ratio of about 1:1, wherein itanapraced and nicotinamide are linked by hydrogen bonding and other non-covalent and non-ionic interactions, the crystalline system is solid at 25° C. and has an X-ray Powder Diffraction Pattern (XRPD) that is substantially the same as the XRPD shown in FIG. 8.
A method of synthesizing a polymorph of a co-crystal of itanapraced and nicotinamide, the method comprising dissolving itanapraced and nicotinamide in dichloromethane to form a solution and precipitating the polymorph of the co-crystal of itanapraced and nicotinamide from the solution.
A method of synthesizing a polymorph of a co-crystal of itanapraced and nicotinamide, the method comprising dissolving itanapraced and nicotinamide in ethyl acetate to form a solution, adding a seed crystal to the solution and precipitating the polymorph of the co-crystal of itanapraced and nicotinamide from the solution.
Dependencies are inferred from the claim text.