Reduction of nitrogen-containing groups in a target compound using a biocatalyst
AssigneeOxford University Innovation Limited
InventorsKylie VINCENT, Holly REEVE, Jack ROWBOTHAM, Sarah CLEARY, Tim SUDMEIER
Life of this patent
Estimating the term…
Abstract
Provided herein is a method of producing a functional group in a target compound using a biocatalyst as described in more detail herein. Also provided are related systems and compositions.
Claims31
1-25. (canceled)
A method of reducing a nitrogen-containing functional group in a target compound, comprising contacting the target compound with a biocatalyst comprising an oxidoreductase enzyme or a functional fragment or derivative thereof supported on a support material, in the presence of a molecular reductant for oxidation by the oxidoreductase enzyme or functional fragment or derivative thereof, under conditions such that:
- the molecular reductant is oxidised by the oxidoreductase enzyme or functional fragment or derivative thereof;
- and
- the nitrogen-containing functional group is reduced at the support material.
A system, comprising:
- i) a biocatalyst comprising an oxidoreductase enzyme or a functional fragment or derivative thereof supported on a support material;
- ii) a molecular reductant;
- and
- iii) a target compound comprising a reducible nitrogen-containing functional group;
- wherein the system is configured such that, in use, (a) the molecular reductant is oxidised by the oxidoreductase enzyme or functional fragment or derivative thereof;
- and (b) the nitrogen-containing functional group is reduced at the support material.
Dependencies are inferred from the claim text.