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US 2026/0042732 A1Published application
Sulfur-containing Compounds and Compositions Thereof for Delivery of Nucleic Acids
AssigneePoseida Therapeutics, Inc.
InventorsMinghao Xu, Lijun Huang, Alicia Davis, Kejin Zhou
Life of this patent
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Abstract
Lipid nanoparticle compositions (LNPs), methods for preparing the LNPs, methods of using the same, including, but not limited to, for treatment of certain diseases and disorders, including, but not limited to liver disorders, kits for the delivery of nucleic acids to various types of cells, including T-cells and hepatocytes, in vivo, ex vivo and in vitro.
Claims101
A compound of Formula (I):
- wherein:
- A is substituted or unsubstituted, branched or unbranched C1-15 aliphatic, substituted or unsubstituted, branched or unbranched C1-15 heteroaliphatic;
- each R1 is independently hydrogen, substituted or unsubstituted, branched or unbranched C1-15 aliphatic, substituted or unsubstituted, branched or unbranched C1-15 heteroaliphatic, wherein at least one occurrence of R1 is hydrogen;
- each of B, C, D is independently hydrogen, substituted or unsubstituted, branched or unbranched C1-15 aliphatic, substituted or unsubstituted, branched or unbranched C1-15 heteroaliphatic, or —(CHR6)CH(SXLY)R6;
- X is S or CH2;
- Y is —OH,
- n=1-3, R″═H or Me;
- L is substituted or unsubstituted, branched or unbranched C1-6 aliphatic, substituted or unsubstituted, branched or unbranched C1-6 heteroaliphatic;
- each R6 is independently hydrogen, substituted or unsubstituted, branched or unbranched C1-15 aliphatic, substituted or unsubstituted, branched or unbranched C1-15 heteroaliphatic, wherein at least one occurrence of R6 is hydrogen;
- or a pharmaceutically acceptable salt thereof.
7 more elements
A compound of the formula:
A compound of Formula (II):
- wherein:
- A is substituted or unsubstituted, branched or unbranched C1-15 aliphatic, substituted or unsubstituted, branched or unbranched C1-15 heteroaliphatic;
- each of R1, R2, R3, and R4 is independently hydrogen, substituted or unsubstituted, branched or unbranched C1-15 aliphatic, or substituted or unsubstituted, branched or unbranched C1-15 heteroaliphatic, wherein at least one occurrence of R1 is hydrogen, at least one occurrence of R2 is hydrogen, at least one occurrence of R3 is hydrogen, and at least one occurrence of R4 is hydrogen;
- X is S or CH2;
- Y is —OH,
- n=1-3, R″═H or Me;
- L is substituted or unsubstituted, branched or unbranched C1-6 aliphatic, substituted or unsubstituted, branched or unbranched C1-6 heteroaliphatic;
- or a pharmaceutically acceptable salt thereof.
5 more elements
A compound of the formula.
A compound of Formula (III):
- wherein:
- each of Ra and Rb is independently
- X is S or CH2;
- Y is —OH,
- n=1-3, R″═H or Me;
- L is substituted or unsubstituted, branched or unbranched C1-6 aliphatic, substituted or unsubstituted, branched or unbranched C1-6 heteroaliphatic;
- R7 is substituted or unsubstituted, branched or unbranched C1-15 aliphatic, substituted or unsubstituted, branched or unbranched C1-15 heteroaliphatic;
- x is an integer between 1 and 10, inclusive;
- y is an integer between 1 and 10, inclusive;
- each Ry and Rz is independently
- or a pharmaceutically acceptable salt thereof.
8 more elements
The compound of the formula:
A compound of Formula (IV):
- wherein:
- each of Re and Rf is independently
- x is an integer between 1 and 10, inclusive;
- each Ry and Rz is independently
- X is S or CH2;
- Y is —OH,
- n=1-3, R″═H or Me;
- L is substituted or unsubstituted, branched or unbranched C1-6 aliphatic, substituted or unsubstituted, branched or unbranched C1-6 heteroaliphatic;
- R7 is substituted or unsubstituted, branched or unbranched C1-15 aliphatic, substituted or unsubstituted, branched or unbranched C1-15 heteroaliphatic;
- or a pharmaceutically acceptable salt thereof.
7 more elements
Dependencies are inferred from the claim text.